Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 24;547:35–46. doi: 10.1016/j.virol.2020.05.005

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Fig. 4 — Placenta histopathology analysis: Hematoxylin and eosin (H&E) staining of placenta labyrinth zone. (a–d) Normal histologic features of the labyrinth (L), junctional zone (JZ), and decidua (D) of the placenta at E14.5 from dams inoculated with PBS (a and b) or DENV-2 (c and d). (e) The interface between the L, the JZ, and the D from a SPONV placenta with numerous intravascular thrombi (*) with apoptotic debris (A) and loss of both maternal and fetal vascular spaces. (f) Higher magnification view of L from a SPONV placenta that shows numerous vascular thrombi (*) with apoptotic debris (A) and loss of both maternal and fetal vascular spaces. (g) The interface of the L, JZ, and D from ZIKV-DAK placenta with numerous intravascular thrombi (*) with apoptotic debris and loss of both maternal and fetal vascular spaces. (h) Higher magnification view of L from a ZIKV-DAK placenta with numerous intravascular thrombi (*) with apoptotic debris and loss of both maternal and fetal vascular spaces. (i) The degree of placental pathology was rated on a scale of 0–4 based on the overall percent of vascular injury and/or loss in both the fetal and maternal vascular spaces of the labyrinth zone: 0 represents 0–5% vasculature injured and/or lost and 4 represents >50% injury/loss. Only labyrinth scores are shown because this was where pathology was primarily observed. Error bars represent 95% confidence interval from the median. Data are representative of 3–6 independent experiments for each treatment group.