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. 2020 Feb 1;61(2):265–274. doi: 10.1093/jrr/rrz099

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© The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — (A) Relationship between EQD2 of the HR-CTV D90 and pretreatment tumor diameter. Closed circles represent patients with local recurrence and open circles indicate patients without recurrence. Red dotted lines show cut-off values of 6 cm (horizontal) and 70 Gy (vertical). The blue dotted line is the regression curve. There was a significant negative correlation between EQD2 of the HR-CTV D90 and pretreatment tumor diameter (r = −0.459, P < 0.001). Percentages in boxes indicate the local recurrence rate for each quadrant. (B) Relationship between EQD2 of the HR-CTV D90 and pretreatment tumor volume. Closed circles represent patients with local recurrence and open circles indicate patients without recurrence. Red dotted lines show cut-off values of 90 cc (horizontal) and 70 Gy (vertical). The blue dotted line is the regression curve. There was a significant negative correlation between EQD2 of the HR-CTV D90 and pretreatment tumor volume (r = −0.513, P < 0.001). Percentages in boxes indicate the local recurrence rate for each quadrant. (C) Relationship between EQD2 of the HR-CTV D90 and the HR-CTV volume at first ICBT. Closed circles indicate patients with local recurrence and open circles represent patients without recurrence. Red dotted lines show cut-off values of 22 cc (horizontal) and 70 Gy (vertical). The blue dotted line is the regression curve. A significant negative correlation was noted between EQD2 of the HR-CTV D90 and the HR-CTV volume at first ICBT (r = −0.713, P < 0.001). Percentages in boxes indicate the local recurrence rate for each quadrant. (D)Relationship between EQD2 of the HR-CTV D90 and the distance from tandem to the lateral border of the HR-CTV. Closed circles represent patients with local recurrence and open circles are for patients without recurrence. Red dotted lines indicate cut-off values of 2.5 cm (horizontal) and 70 Gy (vertical). The blue dotted line shows the regression curve. A negative correlation was recognized between EQD2 of the HR-CTV D90 and the distance from tandem to the lateral border of the HR-CTV (r = − 0.685, P < 0.001). Percentages in boxes indicate the local recurrence rate for each quadrant.