Table 5.
Comparison of reported clinical outcomes of radiotherapy for uterine cervical cancer in Japan
| Author | n | Type of IGBT | Pretreatment tumor size | HR-CTV vo lume at initial IGBT | EBRT Dose/fr | IGBT Dose/fr | LC rate | Findings | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| I | II | Ill | IV | all | ||||||||
| Murakami et al. [5] | 51 | ICBT | I.8–7.7 cm | 8.3—I 00.8 cc | WP20-50Gy | 6 Gy/fr/point A | 3 years | Better LC | ||||
| National | median 4.5 cm | median 23.3 cc | (median 30Gy) | Total EQD2 | NA | NA | NA | NA | 90% | HR-CTV D90 < 60 Gy vs 60 Gy | ||
| Cancer Center | 52.7–101.7 Gy (median 65.0 Gy) | |||||||||||
| Ohno et al. [7] | 80 | ICBT66 | < 4 cm 29 | NA | WP 30 Gy + CS 20 Gy | IGBT 24 Gy/4 fr/HR-CTV D90 | 5 years | Better results with HR-CTV D90 > 60 Gy | ||||
| Gunma | lCBT +needle 14 | 4–6 cm 34 | WP 30–40 Gy + CS 10–20 Gy | HR-CTV D90 > 60Gy 90% | 94% | 97% | 89% (lll | +lV) | 94% | |||
| Univ. | >6 cm 30 | (Bulky case) | ||||||||||
| Kusa da et al. [8] | 68 | IC BT 68 | 2.4–9.3 cm | IO—128 cc | WP 20-56Gy (median 40 Gy) | 18 Gy/3 fr/Point A | 2 years | OS and LC were signi ficant with | ||||
| Ryukyu Univ. | median 4.6 cm | median 28 cc | CSNA Total 39.6–56 Gy | 86% | 83% | 83% | 50% | 83% | HR-CTV D90 < 60 Gy vs > 60 Gy | |||
| (median 50 Gy) | ||||||||||||
| Okazaki et al. [9] | 103 | ICBT94 | < 4 cm 23 | NA | WP 19.8–45 Gy | 3–5 fr (median 4 fr) | 2 years | HR-CTV D90 at BT >36Gy vs <36Gy | ||||
| Saitama Medical | IC BT + IS BT 9 | 4–6 cm 50 > 6 cm 24 | (median 30 Gy) CS 5.4–30 Gy | HR-CTV D90 25.9–55.9 Gy (median 40.5 Gy) | 100% | 96% | 87% (lll | +IV) | NA | sig nificant for LC | ||
| Univ. | (median 20 Gy) | Total EQD2 50.4–90.9 Gy | ||||||||||
| (median 74.2 Gy) | ||||||||||||
| Current Study | 89 | ICBT 89 | 1. 5–11 cm | IO—108.7 cc | WP 30–50.4 Gy | 1 2–24 Gy/2–4 fr/Point A | 3 year | Better res ults with EQD2 HR-CTV | ||||
| median 5.2 cm | median 18.2 cc | (median 40 Gy) | Total EQD2 50.4–109.6 Gy | 100% | 66.5% | 64.9% | 68.6% | 68.8% | D90 > 70 Gy, HR-CTV < 22 cc | |||
| <3 cm 21 | CS 3.6–22 Gy | (median 69.8 Gy) | Tandem to | |||||||||
| 3–6 cm 53 > 6 cm 24 | (median 12 Gy) | lateral border HR-CTV <2.5 cm | ||||||||||
NA = Not assessed, WP = whole pelvis, CS = central shielding, OS = overall survival, BT = brachytherapy, LC = local control.