Table 1.
Factors Predictive of Remission of Chronic Anterior Uveitis in the Adjusted analysis (Hazard Ratios Less than 1 are Unfavorable, Indicating a Lower Incidence of Remission)†
| Remission | Crude | Adjusted* | ||||||
|---|---|---|---|---|---|---|---|---|
| Total | No | Yes | Hazard Ratio (95% CI) | P | Hazard Ratio (95% CI) | P | ||
| Duration of uveitis prior to presentation | <6 Months | 834 (30%) | 593 (71%) | 241 (29%) | Ref | <0.001 | Ref | 0.02 |
| 6 Months to <2 Years | 620 (22%) | 464 (75%) | 156 (25%) | 0.81 (0.63, 1.05) | 0.78 (0.60, 1.03) | |||
| 2 to <5 Years | 512 (18%) | 414 (81%) | 98 (19%) | 0.58 (0.43, 0.78) | 0.61 (0.44, 0.83) | |||
| 5+ Years | 829 (30%) | 662 (80%) | 167 (20%) | 0.63 (0.48, 0.81) | 0.76 (0.58, 1.01) | |||
| Bilateral | No | 379 (14%) | 283 (75%) | 96 (25%) | Ref | 0.008 | Ref | 0.02 |
| Yes | 2416 (86%) | 1850 (77%) | 566 (23%) | 0.73 (0.58, 0.92) | 0.75 (0.59, 0.96) | |||
| Prior cataract surgery | No | 2231 (80%) | 1698 (76%) | 533 (24%) | Ref | 0.03 | Ref | 0.002 |
| Yes | 564 (20%) | 435 (77%) | 129 (23%) | 0.80 (0.65, 0.97) | 0.70 (0.56, 0.88) | |||
| Any glaucoma surgery | No | 2627 (94%) | 1995 (76%) | 632 (24%) | Ref | 0.001 | Ref | 0.01 |
| Yes | 168 (6%) | 138 (82%) | 30 (18%) | 0.59 (0.43, 0.81) | 0.63 (0.45, 0.90) | |||
| Anterior chamber cells at baseline | Quiet | 1153 (43%) | 884 (77%) | 269 (23%) | Ref | <0.001 | Ref | <0.001 |
| 0.5+ | 530 (20%) | 369 (70%) | 161 (30%) | 1.46 (1.17, 1.83) | 1.48 (1.17, 1.87) | |||
| 1+ | 472 (18%) | 377 (80%) | 95 (20%) | 0.89 (0.68, 1.16) | 0.88 (0.66, 1.17) | |||
| ≥2+ | 526 (20%) | 421 (80%) | 105 (20%) | 0.79 (0.61, 1.02) | 0.87 (0.66, 1.15) | |||
| Keratic precipitates | No | 2079 (83%) | 1580 (76%) | 499 (24%) | Ref | <0.001 | Ref | <0.001 |
| Yes | 430 (17%) | 334 (78%) | 96 (22%) | 0.37 (0.22, 0.61) | 0.36 (0.21, 0.60) | |||
| Synechia | Neither | 1940 (72%) | 1459 (75%) | 481 (25%) | Ref | <0.001 | Ref | 0.008 |
| Peripheral Synechia Only | 61 (2%) | 43 (70%) | 18 (30%) | 0.74 (0.42, 1.29) | 0.69 (0.36, 1.32) | |||
| Posterior Synechia Only | 604 (23%) | 488 (81%) | 116 (19%) | 0.67 (0.55, 0.83) | 0.72 (0.58, 0.90) | |||
| Posterior and Peripheral Synechia | 79 (3%) | 66 (84%) | 13 (16%) | 0.56 (0.38, 0.84) | 0.62 (0.41, 0.93) | |||
| Juvenile Idiopathic Arthritis | No | 2192 (78%) | 1602 (73%) | 590 (27%) | Ref | <0.001 | Ref | <0.001 |
| Yes | 603 (22%) | 531 (88%) | 72 (12%) | 0.34 (0.25, 0.47) | 0.37 (0.26, 0.53) | |||
| Spondyloarthropathy | No | 2525 (90%) | 1899 (75%) | 626 (25%) | Ref | <0.001 | Ref | <0.001 |
| Yes | 270 (10%) | 234 (87%) | 36 (13%) | 0.41 (0.27, 0.62) | 0.35 (0.23, 0.54) | |||
| Age at presentation | <40 | 1384 (50%) | 1106 (80%) | 278 (20%) | Ref | <0.001 | Ref | 0.03 |
| 40+ | 1411 (50%) | 1027 (73%) | 384 (27%) | 1.77 (1.46, 2.16) | 1.29 (1.02, 1.63) | |||
†
Includes pa4ents who did not return for follow-up after 90 days, but had 1 or more follow-up visits before 90 days and had remained inactive without receiving suppressive medications at all of those visits, as being in remission.
*
Adjusted for age at presentation, bilateral, duration of uveitis prior to presentation, prior cataract surgery, any glaucoma surgery, anterior chamber cells at baseline, keratic precipitates, synechia, juvenile idiopathic arthritis, spondyloarthropathy