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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Neurocrit Care. 2020 Aug;33(1):140–151. doi: 10.1007/s12028-019-00871-9

Figure 1: Cytokine analysis of patients with subarachnoid hemorrhage (SAH) and a mouse model of SAH show overlapping cytokines.

Figure 1:

Schematic of experimental plan. Cytokine analysis of Day 3 CSF of patients with SAH dichotomized between patients who had a good outcome (defined by mRS 0–2) versus poor outcome (mRS 3–5) shows that five cytokines, TNFα, sTREM-1, IL-1α, IL-17 and IL-2, discriminate patients who go on to have good versus poor outcome (above dotted line). Similarly, cytokine analysis of brain homogenates 3 days after SAH shows that three cytokines are significantly different between mice with SAH versus sham, MIP-2, IL-17, and IL-2 (below dotted line). IL-17 and IL-2 are similarly increased in both human SAH and mouse SAH (Box). Student’s T test p≤ 0.05 defined statistical significance.