Table 1:

Proteomics array analytes tested in human and mouse experiments. Five analytes from cerebrospinal fluid tested three days after subarachnoid hemorrhage (SAH) were significantly different between patients who had good 90-day outcomes (mRS 1–2) versus those that had poor outcomes (mRS 3–5): IL-1α, IL-2, IL-17, TNF- α, and TREM-1 (Student’s t-test; p≤ 0.05). Two analytes were significantly different in the brains of mice three days after SAH or sham surgery: IL-2 and IL-17 (Student’s t-test; p≤ 0.05). (-) Indicates that the analyte was not present on the array; NS signifies not significantly different. Significantly different analytes are highlighted in grey (See figure 1 for more detail). IL-2 and IL-17 were significantly different in both species.

Name	Alternate name	Human	Mouse	Name	Alternate name	Human	Mouse
IL-1α	IL-1F1	p=0.017	NS	C5/C5a		NS	NS
IL-1β	IL-1F2	NS	NS	G-CSF		NS	NS
IL-1ra	IL1-F3	NS	NS	GM-CSF		NS	NS
IL-2		p=0.030	p=0.030	IFN-γ		p=0.054	NS
IL-4		NS	NS	s-ICAM	CD54	NS	NS
IL-5		NS	NS	TNF-α		p=0.047	NS
IL-6		NS	NS	TREM-1		p=0.049	NS
IL-10		NS	NS	IL-3		-	NS
IL-12 p70		NS	NS	IL-7		-	NS
IL-13		NS	NS	IL-17E		NS	-
IL-16		NS	NS	IL-32a		NS	-
IL-17		p=0.044	p=0.040	CCL11	Eotaxin	-	NS
IL-23		NS	NS	CCL12	MCP-5	-	NS
IL-27		NS	NS	CCL17	TARC	-	NS
CCL2	MCP-1	NS	NS	CXCL2	MIP-2	-	p=0.030
CCL3	MIP-1α	NS	NS	CXCL9	MIG	-	NS
CCL4	MIP-1β	NS	NS	CXCL13	BLC	-	NS
CCL5	RANTES	NS	NS	CD40L		NS	-
CXCL1/IL-8	*	P=0.053	NS	MIF		NS	-
CXCL10	IP-10	NS	NS	M-CSF		-	NS
CXCL11	I-TAC	NS	NS	SerpinE1	PAI-1	NS	-
CXCL12	SDF-1	NS	NS	TIMP-1		-	NS

^*CXCL1 in mice and CXCL8/IL-8 in humans serve homologous functions although they are not orthologs. Individual mean and standard error values are presented in Supplemental Table 1.