Table 1:
Participant Characteristics
| Characteristic | Control (N=8) | Sleep-deprived (N=8) |
|---|---|---|
| Age, yr | ||
| Mean | 42.9 | 43.1 |
| SD | 4.3 | 4.3 |
| Sex, M/F | 2/6 | 2/6 |
| Race, C/AA | 5/3 | 5/3 |
| Body mass index, kg/m2 | ||
| Mean | 27.7 | 28.4 |
| SD | 1.5 | 2.1 |
| MMSE | ||
| Mean | 29.3 | 29.1 |
| SD | 0.3 | 0.3 |
| Aβ42:Aβ40 | ||
| Mean | 0.19 | 0.18 |
| SD | 0.02 | 0.01 |
| Pre-CRU actigraphy | ||
| Amplitude, activity counts | ||
| Mean | 126.2 | 95.7 |
| SD | 90.0 | 34.8 |
| Acrophase, hours | ||
| Mean | 6.8 | 7.1 |
| SD | 1.2 | 2.6 |
| Mesor, activity counts | ||
| Mean | 132.2 | 136.7 |
| SD | 63.2 | 56.0 |
| CRU sleep parameters | ||
| Total sleep time, min | ||
| Mean | 413.4 | 36.6* |
| SD | 24.8 | 15.8 |
| Sleep efficiency, % | ||
| Mean | 72.0 | 6.7* |
| SD | 3.4 | 2.9 |
| Adverse Events | ||
| Headaches | 7/8 | 5/8 |
| Blood Patch | 0/8 | 3/8 |
| Presyncope/Syncope | 1/8 | 0/8 |
| Leg Tingling | 1/8 | 1/8 |
| Nausea/Vomiting | 0/8 | 2/8 |
| Back/Neck Pain | 2/8 | 1/8 |
Intervention groups include repeat participants and are not independent groups. Data are shown this way to highlight effect of sleep conditions in each group. Significance tests for treatment differences were made using mixed models to accommodate the nonindependence of the measurements.
Statistically significant. Total sleep time and sleep efficiency are significantly lower in the sleep-deprived condition compared to control (total sleep time: F1,166 = 201.5, p<0.0001; sleep efficiency: F1,8 = 139.8, p<0.0001).
Yr: Year; SD: Standard deviation; M: Male; F: Female; C: Caucasian; AA: African-American; kg: kilogram; m2: meters squared; MMSE: Mini-Mental State Exam; Aβ: Amyloid-β; CRU: clinical research unit; min: minute