Table 2:
Comparison of cosinor parameters between interventions and biofluid compartments for cortisol.
| Dependent Variable | Test | Pairwise Comparison | Estimate (95% CI) | Estimated Difference (estimate, 95% CI) | F (df) | p-value |
|---|---|---|---|---|---|---|
| Amplitude (%) | ||||||
| Intervention | CSF control vs. CSF SD | CSF control: 54.35 (44.22 – 64.48) CSF SD: 54.77 (44.64 – 64.90) |
−0.42 (−12.8 – 12.0) | 0.007 (1,6) | 0.94 | |
| Intervention | Plasma control vs. Plasma SD | Plasma control: 50.82 (39.01 – 62.62) Plasma SD: 51.96 (40.16 – 63.76) |
−1.15 (−9.0 – 6.7) | 0.15 (1,4) | 0.71 | |
| Compartment | CSF control vs. Plasma control | CSF control: 55.35 (41.58 – 69.12) Plasma control: 53.06 (39.29 – 66.83) |
+2.30 (−3.6 – 8.2) | 0.86 (1,7) | 0.38 | |
| Compartment | CSF SD vs. Plasma SD | CSF SD: 56.36 (45.34 – 67.38) Plasma SD: 53.93 (42.91 – 64.95) |
+2.42 (−6.3 – 11.2) | 0.43 (1,7) | 0.53 | |
| Acrophase (hr) | ||||||
| Intervention | CSF control vs. CSF SD | CSF control: 2.05 (0.48 – 3.61) CSF SD; 2.56 (0.99 – 4.12) |
−0.51 (−1.7 – 0.7) | 1.54 (1,4) | 0.29 | |
| Intervention | Plasma control vs. Plasma SD | Plasma control: 0.57 (−0.83 – 1.97) Plasma SD: −0.32 (−1.72 – 1.08) |
+0.89 (−0.6 – 2.4) | 2.82 (1,4) | 0.17 | |
| Compartment | CSF control vs. Plasma control |
CSF control: 2.75 (1.58 – 3.92) Plasma control: 1.13 (−0.048 – 2.30) |
+1.63 (0.8 – 2.5) | 21.5 (1,7) | 0.002 | |
| Compartment | CSF SD vs. Plasma SD |
CSF SD: 2.00 (0.11 – 3.89) Plasma SD: −0.75 (−2.64 – 1.14) |
+2.75 (2.0 – 3.5) | 70.6 (1,7) | <0.0001 | |
| Mesor (%) | ||||||
| Intervention | CSF control vs. CSF SD | CSF control: 86.42 (67.18 – 105.66) CSF SD: 93.36 (74.12 – 112.60) |
−6.94 (−40.5 – 26.7) | 0.21 (1,10) | 0.66 | |
| Intervention | Plasma control vs. Plasma SD | Plasma control: 99.26 (87.95 – 110.56) Plasma SD: 112.96 (101.66 – 124.26) |
−13.70 (−32.1 – 4.7) | 2.82 (1,9) | 0.13 | |
| Compartment | CSF control vs. Plasma control | CSF control: 83.99 (69.77 – 98.20) Plasma control: 99.50 (85.29 – 113.72) |
−15.52 (−32.1 – 1.1) | 4.90 (1,7) | 0.06 | |
| Compartment | CSF SD vs. Plasma SD |
CSF SD: 92.27 (72.88 – 111.66) Plasma SD: 112.10 (92.71 – 131.49) |
−19.82 (−38.9 – −0.7) | 6.02 (1,7) | 0.04 | |
| Linear Rise (%/hr) | ||||||
| Intervention | CSF control vs. CSF SD | CSF control: 0.40 (−0.67 – 1.471) CSF SD: 0.17 (−0.90 – 1.23) |
+0.24 (−1.6 – 2.1) | 0.08 (1,10) | 0.78 | |
| Intervention | Plasma control vs. Plasma SD | Plasma control: −0.08 (−0.76 – 0.60) Plasma SD: −0.64 (−1.32 – 0.04) |
+0.57 (−0.5 – 1.6) | 1.55 (1,9) | 0.24 | |
| Compartment | CSF control vs. Plasma control | CSF control: 0.55 (−0.21 – 1.31) Plasma control: −0.08 (−0.84 – 0.69) |
+0.63 (−0.3 – 1.6) | 2.57 (1,7) | 0.15 | |
| Compartment | CSF SD vs. Plasma SD | CSF SD: 0.22 (−0.91 – 1.35) Plasma SD: −0.64 (−1.76 – 0.49) |
+0.85 (−0.1 – 1.8) | 4.58 (1,7) | 0.70 |
CI: confidence intervals; df: degrees of freedom; CSF: cerebrospinal fluid; SD: sleep deprivation; hr: hour