Table 5:
Comparison of cosinor parameters between interventions and isoforms for CSF Aβ40 and Aβ42
| Dependent Variable | Test | Pairwise Comparison | Estimate (95% CI) | Estimated Difference (estimate, 95% CI) | F (df) | p-value |
|---|---|---|---|---|---|---|
| Aβ40 | ||||||
| Amplitude (%) | Intervention | CSF control vs. CSF SD | CSF control: 9.10 (4.76 – 13.45) CSF SD: 9.03 (4.68 – 13.37) |
+0.07 (−6.14 – 6.29) | 0.001 (1,9) | 0.98 |
| Acrophase (hr) | Intervention | CSF control vs. CSF SD | CSF control: 10.22 (5.05 – 15.39) CSF SD: 5.83 (0.66 – 10.99) |
+4.4 (−3.2 – 12.0) | 1.8 (1,8) | 0.22 |
| Mesor (%) | Intervention | CSF control vs. CSF SD | CSF control: 81.88 (71.13 – 92.64) CSF SD: 80.96 (70.21 – 91.72) |
+0.92 (−18.7 – 20.6) | 0.01 (1,9) | 0.92 |
| Linear Rise (%/hr) | Intervention | CSF control vs. CSF SD | CSF control: 0.96 (0.36 – 1.55) CSF SD: 1.13 (0.53 – 1.72) |
−0.17 (−1.23 – 0.89) | 0.13 (1,9) | 0.73 |
| Aβ42 | ||||||
| Amplitude (%) | Intervention | CSF control vs. CSF SD | CSF control: 8.96 (4.67 – 13.25) CSF SD: 10.75 (6.46 – 15.04) |
−1.79 (−7.75 – 4.18) | 0.5 (1,9) | 0.52 |
| Acrophase (hr) | Intervention | CSF control vs. CSF SD | CSF control: 7.54 (1.61 – 13.47) CSF SD: 5.94 (0.01 – 11.87) |
+1.6 (−7.98 −11.2) | 0.14 (1,10) | 0.72 |
| Mesor (%) | Intervention | CSF control vs. CSF SD | CSF control: 80.17 (69.61 – 90.73) CSF SD: 77.20 (66.63 – 87.76) |
+2.97 (−15.3 – 21.2) | 0.13 (1,10) | 0.72 |
| Linear Rise (%/hr) | Intervention | CSF control vs. CSF SD | CSF control: 1.08 (0.50 – 1.67) CSF SD: 1.35 (0.76 – 1.93) |
−0.26 (−1.27 – 0.74) | 0.34 (1,10) | 0.58 |
| Aβ Control | ||||||
| Amplitude (%) | Isoform | CSF Aβ40 vs. CSF Aβ42 | CSF Aβ40: 9.08 (5.75 – 12.41) CSF Aβ42: 8.90 (5.57 – 12.22) |
+0.19 (−2.35 – 2.72) | 0.03 (1,7) | 0.87 |
| Acrophase (hr) | Isoform | CSF Aβ40 vs. CSF Aβ42 | CSF Aβ40: 10.13 (5.72 – 14.53) CSF Aβ42: 7.81 (3.41 – 12.22) |
+2.3 (−3.01 – 7.6) | 1.1 (1,7) | 0.34 |
| Mesor (%) | Isoform | CSF Aβ40 vs. CSF Aβ42 | CSF Aβ40: 85.04 (73.25 – 96.84) CSF Aβ42: 82.09 (70.30 – 93.89) |
+2.95 (−0.07 – 5.97) | 5.4 (1,7) | 0.05 |
| Linear Rise (%/hr) | Isoform | CSF Aβ40 vs. CSF Aβ42 |
CSF Aβ40: 0.80 (0.15 – 1.45) CSF Aβ42: 0.98 (0.33 – 1.63) |
−0.19 (−0.36 - −0.01) | 6.4 (1,7) | 0.04 |
| Aβ Sleep-Deprived | ||||||
| Amplitude (%) | Isoform | CSF Aβ40 vs. CSF Aβ42 | CSF Aβ40: 8.89 (−4.61 – 1.06) CSF Aβ42: 10.66 (4.98 – 16.34) |
−1.78 (−4.6 – 1.1) | 2.2 (1,7) | 0.18 |
| Acrophase (hr) | Isoform | CSF Aβ40 vs. CSF Aβ42 | CSF Aβ40: 5.94 (−1.37 – 13.24) CSF Aβ42: 5.88 (−1.43 – 13.18) |
+0.063 (−.87 – 0.996) | 0.03 (1,7) | 0.88 |
| Mesor (%) | Isoform | CSF Aβ40 vs. CSF Aβ42 |
CSF Aβ40: 80.95 (68.40 – 93.50) CSF Aβ42: 76.47 (63.92 – 89.02) |
+4.48 (2.7 – 6.3) | 35.5 (1,7) | 0.001 |
| Linear Rise (%/hr) | Isoform | CSF Aβ40 vs. CSF Aβ42 |
CSF Aβ40: 1.13 (0.43 – 1.82) CSF Aβ42: 1.38 (0.69 – 2.08) |
−0.26 (−0.35 – −0.16) | 40.9 (1,7) | <0.001 |
Aβ: amyloid-beta; CI: confidence intervals; df: degrees of freedom; CSF: cerebrospinal fluid; SD: sleep deprivation; hr: hour