Fig. 1.

CIA induction and examination protocol: mice were immunized with CII in the presence of CFA (day 0, first immunization) and with CII in the presence of LPS (day 21, second immunization, ip: intraperitoneal). EPS-37 (or LTA-37, or ArGal) were given to mice systemically—intravenously (iv) or subcutaneously (sc) three times a week starting on the day of second immunization (day 21) till the end of the experiment. Development of arthritis was examined by visual observation, paw thickness measurement and, finally, the level of anti-CII antibodies was measured in the mouse serum