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. 2020 May 25;68(3):17. doi: 10.1007/s00005-020-00581-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Differential effects of intravenous and subcutaneous administration of pure EPS-37 on the development of CIA. Mice immunized with CII in the presence of CFA (day 0, first immunization, sc) and with CII in the presence of LPS (day 21, second immunization, ip) were given saline (open circles) or EPS-37 (black circles) systemically, intravenously (a) or subcutaneously (b) three times a week starting on the day of second immunization (day 21) till the end of the experiment. Results are expressed as arthritis incidence—the percentage of mice with signs of arthritis and arthritis score expressed in points ± SEM. Data represent one out of three similar experiments