Table 2.

Evidence of a subgroup from traits tested within either Composite International Diagnostic Interview Short Form (CIDI-SF) depression or broad depression in the UK Biobank.

Depression definition	Subgroup trait	Variants	βGRS	Depression cases/controls	Subgroup P-value
CIDI-SF	Schizophrenia	180	0.077	15,311/36,811	0.42
	Bipolar disorder	436	0.062	8140/19,466	0.62
	Attention deficit/hyperactivity disorder	342	0.028	8522/21,030	0.11
	Autism spectrum disorder	242	0.057	13,138/31,598	0.12
	Anorexia nervosa	169	0.016	16,024/38,388	0.47
	Inflammatory bowel disease	954	7.37 × 10−3	2186/5265	0.46
	Obesity 3	61	0.038	22,096/53,312	0.55
Broad	Bipolar disorder	435	0.041	11,531/22,186	0.60
	Attention deficit/hyperactivity disorder	342	0.034	12,345/23,844	0.07
	Autism spectrum disorder	242	0.051	18,802/36,000	0.15
	Anorexia nervosa	169	7.87 × 10−3	22,946/43,644	0.79
	Inflammatory bowel disease	219	8.02 × 10−3	22,738/43,355	0.64

The number of individuals classified as depression cases and depression controls is provided. The number of variants assessed and the genetic risk score beta coefficient (β_GRS, representing the upper bound of the heterogeneity proportion) using the optimum variant selection criterion for that trait (as provided in Table 1).