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. 2020 May 19;12:3651–3659. doi: 10.2147/CMAR.S250394

Table 3.

The Mutation or Abnormal Expression Frequency of BOTs-Related Genes

Gene SBOTs MBOTs
MAPK Pathway Activation5658,63 BRAF mutation 23–48% 0.0%
KRAS mutation 17–39.5% 92.3%
ERBB2 mutation/Amplification 6% 3.8%/11.5%
Claudin-1 overexpression 26.3% NA
PI3K/AKT Pathway Activation57,64 p53 mutation/Overexpression Overexpression 11.5%
CDKNA2 mutation NA 19.2%
PTEN mutation NA 3.8%
PIK3CA mutation NA 15.4%
Hedgehog Pathway Activation74 SHH positive expression 42.8% 0.0%
IHH positive expression 14.3% 0.0%
DHH positive expression 71.4% 12.5%
PTCH positive expression 71.4% 62.5%
SMO positive expression 42.8% 62.5%
GLI1 positive expression 57.1% 37.5%
Clarification of Mucinous Subtype & Indicators for the Malignant Features TFF3 strong expression66 0.0% 61.4%
IMP3 strong expression68 8.3% 42.2%