Figure 1.

Histological analysis of sciatic nerve tissue (hematoxylin-eosin staining, ×400). Myelinated nerve fibers of the sciatic nerve in the NC group appear normal and are closely arranged, the axon and its surrounding myelin sheath structure are clear, and the stroma is evenly stained (A). As indicated by the arrow, the arrangement of nerve fibers is disordered, the nerve fibers are demyelinated, with atrophied or even absent axons disappeared in the DM group (B). After LA treatment, the pathological changes in the sciatic nerve show significant improvement (C).

Abbreviations: DM, diabetic model; LA, lipoic acid treatment; NC, normal control.