Table 2.

Main Results of the REACH and REACH-2 Randomized Trials

Study Results	Clinical Trial
	REACH [16]	REACH-2 [18]
Overall survival
Median (95% CI) Months
Experimental arm	9.2 (8.1–10.6)	8.5 (7–10.6)
Control arm	7.6 (6–9.3)	7.3 (5.4–9.1)
Hazard Ratio (95% CI)	0.87 (0.72–1.05)	0.71 (0.53–0.95)
Progression free survival
Median (95% CI) Months
Experimental arm	2.8 (2.7–3.9)	2.8 (2.8–4.1)
Control arm	2.1 (1.6–2.7)	1.6 (1.5–2.7)
Hazard Ratio (95% CI)	0.63 (0.52–0.75)	0.45 (0.34–0.60)
Objective response rate
Percentage of participants
Experimental arm	7.1%	4.6%
Control arm	0.7%	1.1%
Disease control rate
Percentage of participants
Experimental arm	56.2%	59.9%
Control arm	45.7%	38.9%