. 2020 May 20;14:1953–1961. doi: 10.2147/DDDT.S233732

Table 3.

Comparison of Pharmacokinetic Parameters of Fimasartan and Atorvastatin After a Single Administration of FDC of Fimasartan 120mg/Atorvastatin 40mg or Loose Combination of Fimasartan 120mg+Atorvastatin 40mg

Drug	Parameter	Geometric Mean		Geometric Mean Ratio (90% CI)	Intra-Subject CV%	Expanded 90% CI
Drug	Parameter	Fimasartan 120mg/ Atorvastatin 40mg (N=56)	Fimasartan 120mg + Atorvastatin 40 mg (N=56)^a	Geometric Mean Ratio (90% CI)	Intra-Subject CV%	Expanded 90% CI
Fimasartan	C_max (μg/L)	332.92	309.57	1.0754 (0.9317–1.2414)	60.56	0.6539–1.5293
Fimasartan	AUC_last (h*μg/L)	898.84	881.21	1.0200 (0.9672–1.0758)	19.18
Atorvastatin	C_max (μg/L)	37.05	36.38	1.0184 (0.9150–1.1334)	44.14	0.7257–1.3780
Atorvastatin	AUC_last (h*μg/L)	102.12	100.06	1.0204 (0.9748–1.0682)	16.66

Note: ^aThe pharmacokinetic parameters are the sum of PK data collected after the first and second co-administration of fimasartan 120 mg + atorvastatin 40mg in 56 subjects.