Table 1.
Results of Checkerboard Assay
| Clinical Strain | Mechanism of Resistance | MIC (µg/mL) | Change of MIC of Gentamicin | Minimal FIC Index | ||
|---|---|---|---|---|---|---|
| Gentamicin | Gentamicin+ SNPs | SNPs+ Gentamicin |
||||
| K/8605/12 | MRSE, MLSB | 500 | 31.25 | 87 | 16 | 0.12 |
| K/4042/16 | MRSE, MLSB | 500 | 31.25 | 175 | 16 | 0.19 |
| K/8399/12 | MRSE, MLSB | 500 | 31.25 | 175 | 16 | 0.19 |
| K/15/928 | MRSE, MLSB | 500 | 7.81 | 87 | 64 | 0.08 |
| K/15/323 | MRSE | 125 | 0.97 | 350 | 128 | 0.26 |
| K/15/534 | MRSE, MLSB | 250 | 31.25 | 87 | 16 | 0.18 |
| K/15/428 | MRSE, MLSB | 500 | 62.5 | 175 | 8 | 0.25 |
| K/15/420 | MRSE, MLSB | 500 | 31.25 | 87 | 16 | 0.13 |
| K/16/3882 | MRSE, MLSB | 500 | 31.25 | 175 | 16 | 0.19 |
Note: Minimal inhibitory concentrations for gentamicin and silver nanoparticles and minimal FIC index for all clinical strains of Staphylococcus epidermidis.
Abbreviations: FIC, fractional inhibitory concentration; MIC, minimal inhibitory concentration; MLSB, macrolide-lincosamide-streptogramin resistance of Staphylococcus epidermidis; MRSE, methicillin-resistant Staphylococcus epidermidis; SNPs, silver nanoparticles.