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. 2020 Jun;36(6):545–559. doi: 10.1016/j.pt.2020.04.003

Figure 1.

Figure 1

Mapping the Critical PfRH5 Epitopes on the RCR Complex.

(A) An illustration of the RCR complex binding basigin on the human erythrocyte based on the cryo-EM structure (EMD-9192, PDB: 6MPV) and crystal structure of PfRH5:basigin (PDB: 4U0Q). (B) RCR bound to basigin. (C) RCR binding basigin-blocking Fabs QA1 (PDB: 4U1G) and R5.004 (PDB: 6RCU). (D) RCR bound to basigin proximal Fabs R5.016 (PDB: 6RCU) and 9AD4 (PDB: 4U0R). (E) RCR bound to synergistic noninhibitory Fab R5.011 (PDB: 6RCV). The basigin binding site on PfRH5 has been coloured blue where basigin is absent in the lower panels. Figure produced using Chimera [87]. Abbreviations: cryo-EM, cryoelectron microscopy; RCR, PfRH5-PfCyRPA-PfRipr; PDB, protein data bank.