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. 2020 Jun;36(6):545–559. doi: 10.1016/j.pt.2020.04.003

Table 2.

Neutralizing Monoclonal Antibodies to the RCR Complex

Antibody Target Isotype Species Concentration
(mg/ml)		 GIA (%)a Cross-strain neutralizing Binding details Refs
BS1.2 PfRH5 IgG Mouse 0.5
0.25
0.125		 35
30
25		 Yes N/A [64]
2AC7 IgG1 Mouse 0.5
0.25
0.125		 80
75
70		 Yes Conformational epitope [51]
9AD4 IgG2a Mouse 0.5
0.25
0.125		 70
60
55		 Yes Linear epitope beginning at Y346, basigin binding adjacent [51]
QA5 IgG1 Mouse 0.5
0.25
0.125		 60
50
45		 Yes Linear epitope beginning at Y194 [51]
6BF10 IgG Mouse 0.5
0.25
0.125		 30
30
30		 Yes Conformational epitope [51]
QA1 IgG Mouse 0.5 35 Yes Conformational epitope, basigin blocking [51]
R5.004 IgG1 Human 0.5
0.25
0.01		 90
80
30		 Yes Conformational epitope, basigin blocking [38]
R5.008 IgG1 Human 0.5
0.25
0.01		 80
75
20		 Yes Conformational epitope, basigin blocking [38]
R5.013 IgG1 Human 0.5
0.25
0.01		 65
50
10		 Yes Conformational epitope, basigin blocking [38]
R5.016 IgG1 Human 0.5
0.25
0.01		 95
85
50		 Yes Conformational epitope, adjacent to basigin binding site [38]
R5.017 IgG1 Human 0.5
0.25
0.01		 90
80
30		 Yes Conformational epitope, basigin blocking [38]
R5.018 IgG1 Human 0.5
0.25
0.01		 50
35
5		 Yes Conformational epitope, basigin blocking [38]
R5.019 IgG1 Human 0.5
0.25
0.01		 90
80
20		 Yes Conformational epitope, basigin blocking [38]
5G6 PfRipr IgG Mouse 0.5
0.25
0.125		 35b
25b
15b 		Unknown Conformational epitope [45]
1G12 IgG Mouse 0.5
0.25
0.125		 50b
35b
25b 		Unknown Conformational epitope [45]
c02 PfCyRPA IgG2b Mouse 0.5
0.25
0.125		 50b
40b
30b 		Yes Conformational epitope between amino acids 26–181 [62]
c04 IgG3 Mouse 0.5
0.25
0.125		 50b
40
30		 Yes Conformational epitope between amino acids 26–181 [62]
c06 IgGa Mouse 0.25
0.125		 50b
40b 		Yes Conformational epitope between amino acids 26–181 [62]
c08 IgG1 Mouse 0.5
0.25
0.125		 30b
20b
15b 		Yes Conformational epitope between amino acids 26–181 [62]
c09 IgG3 Mouse 0.5
0.25
0.125		 50b
40b
30b 		Yes Conformational epitope between amino acids 26–181 [62]
c10 IgG1 Mouse 0.5
0.25
0.125		 45b
35b
25b 		Yes Conformational epitope between amino acids 26–352 [62]
c12 IgG2a Mouse 0.5
0.25
0.125		 50b
40b
30b 		Yes Conformational epitope on blades 2–3 [62]
SB1.6 IgG Mouse 0.5
0.25
0.125		 65b
50b
35b 		Unknown Conformational epitope between amino acids 74–251 [65]
SB2.1 IgG Mouse 0.5
0.25
0.125		 50b
40b
30b 		Unknown Conformational epitope between amino acids 74–251 [65]
SB2.3 IgG Mouse 0.5
0.25
0.125		 50b
40b
30b 		Unknown Conformational epitope between amino acids 74–251 [65]
SB3.3 IgG Mouse 0.5
0.25
0.125		 40b
30b
20b 		Unknown Conformational epitope between amino acids 74–251 [65]
5B12 IgG Mouse 2 70b Unknown Conformational epitope [63]
3D1 IgG Mouse 2 70b Unknown Conformational epitope [63]
8A7 IgG1 Mouse 2 70b Unknown Conformational epitope on blades 2–3 [63]
a

Abbreviation: GIA, growth inhibition activity.

b

Based on only two-cycle growth inhibition while all others are based on one cycle.