Table 2.
Percentages of lymphocyte subpopulations in each age group
| Population |
Cord blood (N = 32) |
<2 y (N = 39) |
2‐5 y (N = 41) |
5‐10 y (N = 28) |
10‐15 y (N = 42) |
P‐value |
|---|---|---|---|---|---|---|
| % CD3+ T cells | 64.1 (57.7‐73.0) | 62.2 (55.6‐66.1) | 64.9 (60.1‐69.5) | 62.0 (51.8‐66.3) | 63.1 (59.3‐66.5) | .09 |
| % CD4+ T cells | 42.5 (37.0‐49.0) | 36.0 (29.5‐39.8) | 33.5 (30.3‐37.5) | 26.8 (24.8‐29.3) | 28.7 (26.9‐35.0) | <.01* |
| % CD8+ T cells | 17.1 (13.1‐24.2) | 18.9 (14.7‐23.9) | 21.4 (18.7‐24.8) | 21.5 (17.4‐26.0) | 23.9 (20.5‐25.7) | <.01* |
| % Regulatory T cells/CD4+ T cells | 2.7 (1.7‐4.2) | 4.9 (4.2‐6.3) | 5.9 (4.6‐6.9) | 4.6 (3.6‐7.3) | 4.0 (3.2‐5.1) | <.01* |
|
% Regulatory T cells (CD4+ CD25+Foxp3+) |
1.0 (0.7‐1.7) | 1.8 (1.3‐2.5) | 2.0 (1.5‐2.4) | 1.4 (1.1‐1.9) | 1.0 (0.9‐1.4) | <.01* |
|
% γδ T cells (CD45+ CD3+ CD4−CD8− γδ TCR+) |
0.6 (0.4‐1.0) | 3.3 (2.4‐4.7) | 6.1 (4.0‐8.2) | 7.4 (5.6‐9.9) | 5.9 (4.5‐9.5) | <.01* |
|
% Double‐negative T cells (CD45+ CD3+ CD4− CD8−) |
1.2 (0.8‐1.5) | 4.6 (3.7‐6.2) | 7.7 (6.0‐9.4) | 10.5 (7.6‐13.2) | 7.6 (5.7‐10.8) | <.01* |
|
% NK cells (CD56+) |
5.0 (2.6‐10.9) | 4.5 (3.5‐7.2) | 7.6 (5.6‐11.5) | 12.6 (8.7‐15.4) | 14.1 (10.0‐17.0) | <.01* |
|
% NK T cells (CD3+ CD56+) |
0.1 (0.0‐0.3) | 0.2 (0.1‐0.4) | 0.7 (0.4‐1.0) | 0.8 (0.5‐1.6) | 0.8 (0.6‐1.5) | <.01* |
| % CD19+ B cells | 12.2 (8.6‐16.0) | 17.8 (13.3‐22.3) | 19.9 (17.5‐22.8) | 21.6 (19.6‐24.2) | 17.1 (14.3‐20.4) | <.01* |
Values were presented as medians along with 25th–75th percentile ranges. Percentages are given with reference to the total number of lymphocytes.
*
Statistically significant at the P < .05 levels.