Table 3.

STRING: Biological Processes (GO), Molecular Function (GO), Cellular Components with KEGG, and Reactome Pathway for the NIPA1 Gene.

GO-term	Description	Count in Gene Set	False Discovery Rate
	Biological Process (GO)
GO:0030509	BMP signaling pathway	10 of 92	3.30 × 10−15
GO:0010862	Positive regulation of pathway restricted SMAD protein phosphorylation	9 of 49	3.30 × 10−15
GO:0061448	Connective tissue development	11 of 194	7.18 × 10−15
GO:0030501	Positive regulation of bone mineralization	8 of 35	1.05 × 10−14
GO:0051216	Cartilage development	10 of 147	3.31 × 10−15
	Molecular Function (GO)
GO:0005160	Transforming growth factor beta receptor binding	7 of 50	1.37 × 10−11
GO:0070700	BMP receptor binding	5 of 9	9.71 × 10−11
GO:0019199	Transmembrane receptor protein kinase activity	6 of 78	5.79 × 10−9
GO:0008083	Growth factor activity	7 of 160	5.79 × 10−9
GO:0005125	Cytokine activity	7 of 216	3.33 × 10−8
	Cellular Component (GO)
GO:0043025	Neuronal cell body	6 of 460	0.00089
GO:1990712	HFE-transferrin receptor complex	2 of 8	0.0026
GO:0005615	Extracellular space	7 of 1134	0.0031
GO:0030425	Dendrite	5 of 531	0.0048
GO:0043235	Receptor complex	4 of 305	0.0052
	KEGG Pathways
HSA04350	TGF-beta signaling pathway	9 of 83	5.28 × 10−15
HSA04390	Hippo signaling pathway	9 of 152	4.68 × 10−13
HSA04060	Cytokine–cytokine receptor interaction	6 of 263	3.07 × 10−6
HSA04360	Axon guidance	5 of 173	8.95 × 10−6
	Reactome Pathways
HSA201451	Signaling by BMP	5 of 27	9.97 × 10−9
HAS9006936	Signaling by TGF-beta family members	6 of 100	3.10 × 10−8
HSA2129379	Molecules associated with elastic fibers	4 of 37	2.03 × 10−6
HSA1474244	Extracellular matrix organization	5 of 298	0.00017
HSA8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	2 of 30	0.0055

Source: STRING.org.