Table 5.
STRING Interactants and Their Functions Related to Other Proteins Associated with NIPA1 Gene.
| GENE | Description |
|---|---|
| NIPA1 | Non-Imprinted in Prader-Willi/Angelman Syndrome Region Protein 1; Acts as a Mg (2+) transporter. Can also transport other divalent cations such as Fe (2+), Sr (2+), Ba (2+), Mn (2+) and Co (2+) but to a much less extent than Mg (2+) Belongs to the NIPA family. |
| TGFB1 | Transforming growth factor beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. |
| BMP4 | Bone morphogenetic protein- 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. |
| BMP6 | Bone morphogenetic protein 6; Induces cartilage and bone formation. |
| BMP8B | Bone morphogenetic protein 8B; Induces cartilage and bone formation. Plays a role in calcium regulation and bone homeostasis; Belongs to the TGF-beta family. |
| MUSK | Muscle, skeletal receptor tyrosine-protein kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. |
| BMPR2 | Bone morphogenetic protein receptor type 2; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases., |
| BMP2 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway |
| BMP7 | Bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. |
| BMPR1B | Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. |
| GDF2 | Growth/differentiation factor 2; Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin. |
Source: STRING.org.