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. 2020 Apr 26;21(9):3055. doi: 10.3390/ijms21093055

Table 5.

Drosophila models of Ataxia Telangiectasia.

Ataxia Telangiectasia
Drosophila Model Developmental Stage Assay Used for Neuropathology References
Drosophila orthologs of human genes
ATM8 mutants and knockdown of ATM Adult Climbing assay, lifespan, histological staining for vacuole quantification, immunostaining with anti–CaspAct for prevalence of apoptosis [155]
ATM8 mutants and knockdown of ATM Adult Concurrent climbing assay, lifespan, histological staining for vacuole quantification, immunostaining with anti–CaspAct for prevalence of apoptosis [156]
ATM3, ATM4, and ATM8 mutants Adult Percent eclosion, lifespan [159]