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. 2020 Apr 27;21(9):3073. doi: 10.3390/ijms21093073

Figure 1.

Figure 1

SOCS2 deletion aggravates colitis severity in mice. (A) Experimental design of dextran sodium sulphate (DSS)-induced colitis. Both wild-type (SOCS2+/+) and SOCS2-knockout (SOCS2−/−) mice were sacrificed at three time points. Prior colitis (Pre-DSS), after DSS-induced colitis and at recovery 12 days after abstaining DSS from drinking water. Percentage of body weight changes (B), macroscopic colitis severity index (C) and histological colitis score (D) in SOCS2+/+ and SOCS2−/− mice at three time points of the model. (E) Hematoxylin and eosin staining of the distal colon from mice at the three time points of the model taken at 10x magnification. Magnified sections (X40) are shown in the bottom left corner. Details of the macroscopic and histological assessments are described in the Methods section. Student’s t-test p-values: # <0.05, ** <0.01, *** <0.001; n = 10 mice per group.