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. 2020 Apr 27;21(9):3073. doi: 10.3390/ijms21093073

Figure 2.

Figure 2

Growth hormone and inflammatory activity during colitis and recovery. (A) Gene expressions of pro-inflammatory (NOS2 and IL-1β) and anti-inflammatory cytokines (IL-4) in colonic tissue prior, during DSS-induced colitis and at recovery in wild-type (SOCS2+/+) and SOCS-knockout (SOCS2−/−) mice. Gene expressions were measured using the relative standard method and normalised to expression of the β-actin gene. Data are shown in relative unit (RU). (B) Plasma cytokine levels of TNFα and plasma IL-4 of in both mice groups. (C) Growth hormone (GH) sensitivity index measured as the ratio of plasma IGF-1/GH in both mice groups during the three time points of the model. * Student’s t-test p-value < 0.05; n = 6 per mice group for the gene expression study and for plasma analysis n = 10 per group.