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. 2020 Apr 26;21(9):3052. doi: 10.3390/ijms21093052

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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High Infiltration of CD45-positive leukocytes was evident at the site of MSC injection in the xenogeneic group. CD45-positive leukocytes were barely observed in the MEM-injected group. Infiltration of CD45-positive leukocytes (positive signals indicated in solid yellow arrows) was discernible at the site of injection. The highest infiltration was observed in the xenogeneic (xeno) group and the lowest in the syngeneic (syn) group. A statistically significant difference was observed when comparing CD45 expression levels between the allogeneic (allo) and xenogeneic (xeno) groups. Statistical significance was defined as *** p < 0.001 vs. xeno (xenogeneic); mean ± S.E.M. (A) Scale bar: whole brain: 2 mm, magnified image: 50 µm.