Figure 1.

Schematic representation of possible mechanisms of the glycocalyx protection by some drugs. Damaging factors cause destruction in eGC, both directly and through various enzymes and mediators, thus impairing endothelial function, decreasing NO bioavailability, enhancing leukocyte adhesion, and increasing thrombogenic potential and endothelial permeability. Red arrows indicate activating and damaging factors and processes. Green arrows point to blocking and protective effects of drugs.