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. 2020 Apr 25;21(9):3035. doi: 10.3390/ijms21093035

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Ex vivo thrombus growth under low shear rate conditions. (a−d) Typical thrombi on fibrillary collagen of ITP:HFB (n = 3, a), ITP:LFB (n = 3, b), GT (n = 4, c) and healthy donors (n = 7, d) after 15 min of hirudinated whole blood perfusion. Method of thrombi area calculation is demonstrated by red dashed areas on the left halves of the panels. (e) Mean thrombus area (dashed lines) ± SD (solid lines) of ITP:HFB (blue), ITP:LFB (green), GT (purple) and healthy donors (black). (f) Mean thrombus area (dashed lines) ± SD (solid lines) of healthy donors (black) and healthy donors with 5-times reduced platelet count (green).