Figure 1.

Prescription distribution per quarter (+SEM) as reported to the Drug Enforcement Administration’s Automated Reports and Consolidated Ordering System expressed as morphine mg equivalents (MME) and corrected for population for opioids used for pain (A) or Opioid Use Disorder (OUD, (B), * P < 0.05 versus pre-legalization), or both (C) during the period before (2007–2012, designated by a vertical dotted line) and after (2013–2017) recreational marijuana legalization in Colorado (CO) relative to comparison states (MD: Maryland, UT: Utah).