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. 2020 May 2;21(9):3229. doi: 10.3390/ijms21093229

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© 2020 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Three hundred sixty-six pluripotency-enriched genes were successfully upreprogrammed to the levels found in human ESCs. (A) A box plot for overall successful upreprogramming of the 366 genes at the transcriptional levels. Dots above or beneath the wiskers are outliers of each group. (B) A heat map showing successful individual upreprogramming of the 366 PSC genes. ESC: human embryonic stem cells (n = 3); H1: ESC cell line H1; H9: ESC cell line H9; OSKM: OCT4, SOX2, KLF4, and c-MYC; F: fibroblasts; BJ: human fibroblasts (n = 4); GFP: human fibroblasts transduced with lentiviral GFP (n = 4). Numbers in each label are the period of time for which transgenes had been introduced into the fibroblasts. Log2-transformed read counts were used to prepare box plots and heat maps. Heat maps were scaled by rows or genes.