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. 2020 Apr 27;21(9):3046. doi: 10.3390/ijms21093046

Figure 2.

Figure 2

The influence of miRNA on angiogenesis process. (A) Hypoxia induces the transcription and Table 1. molecules. miR-210-3p and miR-21 act as a costimulators, intensifying expression. HIF-1 α cooperates with HIF-1β subunits and various complementary molecules such as p300, STAT-3 and myc-associated zinc finger protein (MAZ) during the transcription of vascular endothelial growth factor (VEGF). miR-125-b interplays with MAZ and a reduced level of miR-125-b results in an increase in MAZ and VEGF expression. miR-128 inhibits VEGF translation directly. (B) VEGF/VEGF receptor (R) axis signals through RAS/RAF-1/MEK/ERK-1/ERK-3. The promotion of this pathway results in intensive angiogenesis and microvascular proliferation. miR-205 inhibits VEGF/VEGFR interplay and miR 7-5p inhibits RAF-1. Both molecules significantly reduce angiogenesis in glioma. miR- 93 influences the expression of molecules by promoting microvascular growth.