Table 1.

Possible drug treatment interventions for CPPS.

Potential Medication	Action Mechanisms	Therapeutics Intervention
Tricyclic antidepressants; sodium pentosapolysulfate	Inhibit reuptake of noradrenaline and serotonin	Improves pain regulation; improves functioning of the downward pain-processing conduits
Resiniferatoxin; capsaicin	Bind to nerve-ending receptors and desensitize pain fibers	Delays nerve conduction velocity
Botulinum toxin	Inhibits the secretion of inflammatory agents such as substance p and nerve growth factors; inhibits production of prostaglandins	Administered due to the assumption that CPPS has an inflammatory source; prevents higher tonus of pelvic muscles
Hormone therapy	Releases hormone agonists	Some success in response to hormone therapy; pain is related to the menstrual cycle and hormonal changes