Table 1.
Levels of CFTR mRNA expression during human foetal development.
| Tissues | 1st Trimester | 2nd Trimester | 3rd Trimester | References |
|---|---|---|---|---|
| Pancreas | +++ | +++ | +++ | [27,30,31,32] |
| Liver | ++ | ++ | ++ | [27,31] |
| Kidneys | ++ | +++ | ++ | [33] |
| Colon and small intestine | +++ | +++ | +++ | [10,27,31] |
| Large airways | + d | + | + | [27,28,29,31] |
| Small airways | + | ++ | + | [27,28,31] |
| Submucosal glands | ND | ND | ND | [28] |
| Epididymis Vas deferens |
+ | + | + | [30,31] |
| Uterus Fallopian tubes |
ND | ND | + | [31] |
Legend: +++ high, ++ medium, + detectable, d diffuse, ND not detectable.