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. 2020 May 9;21(9):3349. doi: 10.3390/ijms21093349

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of lenvatinib treatment on Toll-like receptor (TLR)-related gene expression in human hepatoma Huh7 and HepG2 cells: (A) Upregulated genes (p < 0.05); (B) Downregulated genes (p < 0.05). (C) Changes of TLR-related gene expression in Huh7 cells treated with or without lenvatinib; (D) Changes of TLR-related gene expression in HepG2 cells treated with or without lenvatinib. Cells were treated with or without 2 μM lenvatinib for 24 h and cellular RNA was extracted. Eighty-four TLR-related genes were evaluated by real-time PCR-based array (n = 3). p-values, compared to those of untreated cells.