Table 3.
The associations between the polymorphisms of CD44 and the EGFR hotspot mutations in male patients with lung adenocarcinoma.
| SNP Genotypes | Wild Type (N = 66) | L858R | Exon 19 in-Frame Deletion | ||
|---|---|---|---|---|---|
| (N = 18) | AOR (95% CI) | (N = 38) | AOR (95% CI) | ||
| rs1425802 | |||||
| AA | 23 (34.8%) | 5 (27.8%) | 1.00 | 19 (50.0%) | 1.00 |
| AG + GG | 43 (65.2%) | 13 (72.2%) | 1.502 (0.462–4.889) | 19 (50.0%) | 0.567 (0.248–1.296) |
| rs187115 | |||||
| AA | 47 (71.2%) | 12 (66.7%) | 1.00 | 24 (63.2%) | 1.00 |
| AG + GG | 19 (28.8%) | 6 (33.3%) | 1.283 (0.416–3.961) | 14 (36.8%) | 1.403 (0.592–3.323) |
| rs713330 | |||||
| TT | 55 (83.3%) | 15 (83.3%) | 1.00 | 32 (84.2%) | 1.00 |
| TC + CC | 11 (16.7%) | 3 (16.7%) | 1.077 (0.256–4.529) | 6 (15.8%) | 1.159 (0.375–3.583) |
| rs11821102 | |||||
| GG | 60 (90.9%) | 13 (72.2%) | 1.00 | 37 (97.4%) | 1.00 |
| GA + AA | 6 (9.1%) | 5 (27.8%) | 3.991 (1.002–16.499) | 1 (2.6%) | 0.167 (0.019–1.496) |
| rs10836347 | |||||
| CC | 59 (89.4%) | 17 (94.4%) | 1.00 | 32 (84.2%) | 1.00 |
| CT + TT | 7 (10.6%) | 1 (5.6%) | 0.488 (0.056–4.263) | 6 (15.8%) | 1.565 (0.474–5.166) |
| rs13347 | |||||
| CC | 24 (36.4%) | 6 (33.3%) | 1.00 | 16 (42.1%) | 1.00 |
| CT + TT | 42 (63.6%) | 12 (66.7%) | 1.165 (0.386–3.519) | 22 (57.9%) | 0.795 (0.346–1.823) |
Abbreviations: SNP, single nucleotide polymorphism; the AORs with 95% CIs were estimated by multiple logistic regression models after controlling for age. AOR, adjusted odds ratio; CI, confidence interval. Bold text indicated a significant association with p-value < 0.05.