Table 4.
The associations between polymorphic genotypes of CD 44 rs713330 and rs10836347 and clinicopathological characteristics of male patients with lung adenocarcinoma.
| Variable Genotypic Frequencies | Tumor AJCC “T” Classification | |||
|---|---|---|---|---|
| T1 + T2 n (%) | T3 + T4 n (%) | AOR (95% CI) | p Value | |
| CD44 (rs713330) All Cases (n = 126) | (n = 72) | (n = 54) | ||
| TT | 65 (90.3%) | 39 (72.2%) | 1.00 | |
| TC + CC | 7 (9.7%) | 15 (27.8%) | 4.250 (1.529–11.814) | p = 0.006 |
| CD44 (rs713330) EGFR Wild Type (n = 66) | (n = 37) | (n = 29) | ||
| TT | 34 (91.9%) | 21 (72.4%) | 1.00 | |
| TC + CC | 3 (8.1%) | 8 (27.6%) | 5.398 (1.203–24.223) | p = 0.028 |
| CD44 (rs713330) EGFR Mutation Type (n = 60) | (n = 35) | (n = 25) | ||
| TT | 31 (88.6%) | 18 (72.0%) | 1.00 | |
| TC + CC | 4 (11.4%) | 7 (28.0%) | 3.490 (0.852–14.297) | p = 0.082 |
| CD44 (rs10836347) All Cases (n = 126) | (n = 72) | (n = 54) | ||
| CC | 65 (90.3%) | 44 (81.5%) | 1.00 | |
| CT + TT | 7 (9.7%) | 10 (18.5%) | 2.194 (0.770–6.250) | p = 0.141 |
| CD44 (rs10836347) EGFR Wild Type (n = 66) | (n = 37) | (n = 29) | ||
| CC | 36 (97.3%) | 23 (79.3%) | 1.00 | |
| CT + TT | 1 (2.7%) | 6 (20.7%) | 9.136 (1.028–81.200) | p = 0.047 |
| CD44 (rs10836347) EGFR Mutation Type (n = 60) | (n = 35) | (n = 25) | ||
| CC | 29 (82.9%) | 21 (84.0%) | 1.00 | |
| CT + TT | 6 (17.1%) | 4 (16.0%) | 1.023 (0.246–4.258) | p = 0.975 |
Note: the AORs with 95% CIs were estimated by multiple logistic regression models after controlling for age. AOR, adjusted odds ratio. CI, confidence interval. Bold text indicated a significant association with p-value < 0.05.