Table A2.
The associations between the polymorphisms of CD44 and the cigarette smoking status in lung adenocarcinoma.
| SNP Genotypes | All Cases (n = 279) | |||
|---|---|---|---|---|
| Never-Smoker (n = 180) | Ever-Smoker (n = 99) | AOR (95% CI) | p Value | |
| rs1425802 | ||||
| AA | 61 (33.9%) | 41 (41.4%) | 1.00 | |
| AG | 81 (45.0%) | 47 (47.5%) | 0.877 (0.408–1.885) | p = 0.736 |
| GG | 38 (21.1%) | 11 (11.1%) | 0.362 (0.129–1.017) | p = 0.054 |
| AG + GG | 119 (66.1%) | 58 (58.6%) | 0.699 (0.341–1.432) | p = 0.328 |
| rs187115 | ||||
| AA | 123 (68.3%) | 69 (69.7%) | 1.00 | |
| AG | 53 (29.4%) | 25 (25.3%) | 0.713 (0.331–1.533) | p = 0.386 |
| GG | 4 (2.2%) | 5 (5.1%) | 2.938 (0.379–22.763) | p = 0.302 |
| AG + GG | 57 (31.7%) | 30 (30.3%) | 0.826 (0.396–1.722) | p = 0.611 |
| rs713330 | ||||
| TT | 156 (86.7%) | 85 (85.9%) | 1.00 | |
| TC | 24 (13.3%) | 12 (12.1%) | 0.407 (0.156–1.061) | p = 0.066 |
| CC | 0 (0%) | 2 (2.0%) | --- | --- |
| TC + CC | 24 (13.3%) | 14 (14.1%) | 0.556 (0.220–1.405) | p = 0.214 |
| rs11821102 | ||||
| GG | 157 (87.2%) | 90 (90.9%) | 1.00 | |
| GA | 21 (11.7%) | 7 (7.1%) | 0.626 (0.184–2.125) | p = 0.452 |
| AA | 2 (1.1%) | 2 (2.0%) | 2.355 (0.117–47.223) | p = 0.576 |
| GA + AA | 23 (12.8%) | 9 (9.1%) | 0.749 (0.239–2.352) | p = 0.621 |
| rs10836347 | ||||
| CC | 153 (85.0%) | 84 (84.8%) | 1.00 | |
| CT | 26 (14.4%) | 15 (15.2%) | 1.467 (0.538–4.004) | p = 0.454 |
| TT | 1 (0.6%) | 0 (0%) | ---- | --- |
| CT + TT | 27 (15.0%) | 15 (15.2%) | 1.448 (0.533–3.934) | p = 0.468 |
| rs13347 | ||||
| CC | 83 (46.1%) | 40 (40.4%) | 1.00 | |
| CT | 83 (46.1%) | 53 (53.5%) | 0.925 (0.446–1.920) | p = 0.835 |
| TT | 14 (7.8%) | 6 (6.1%) | 0.454 (0.121–1.707) | p = 0.243 |
| CT + TT | 63 (53.9%) | 59 (59.6%) | 0.842 (0.415–1.707) | p = 0.633 |
The AORs with 95% CIs were estimated by multiple logistic regression models after controlling for age and gender. Abbreviations: SNP, single nucleotide polymorphism; AOR, adjusted odds ratio; CI, confidence interval.