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Death effector domain (DED) chains and procaspase-8 transprocessing. (a) Activation of procaspase-8 begins with DED chains, which consist of procaspase-8 p55/p53, procaspase-10 and c-FLIP. (b) Procaspase-8 homodimers are converted into active caspase-8 heterotetramers p182/p102 via the intermediate procaspase-8 p43/p41.
