Table 1.
TNM staging for HPV+ oropharyngeal cancer (8th edition). LNs = Lymph Nodes, OSCC = Oropharyngeal Squamous Cell Carcinoma, TNM = Tumor Node Metastasis.
| HPV+ OSCC | Clinical Stage | Pathologic Stage | ||||
|---|---|---|---|---|---|---|
| Category | T | N | M | T | N | M |
| Stage I | T1, T2 | N0: No regional LNs | M0 | T1, T2 | N0: no regional LNs | M0 |
| N1: Ipsilateral LNs | N1: 1–4 LNs | |||||
| Stage II | T1, T2 | N2: bilateral or contralateral LNs | M0 | T1, T2 | N2: ≥ 5 LNs | M0 |
| T3 | N0: no regional LNs N1: ipsilateral LNs N2: bilateral or contralateral LNs |
M0 | T3, T4 | N0: no regional LNs N1: 1–4 LNs |
||
| Stage III | T4 | Any N | M0 | T3, T4 | N2: ≥ 5 LNs | M0 |
| Any T | N3: > 6 cm LN(s) | M0 | ||||
| Stage IV | Any T | Any T | M1 | Any T | Any N | M1 |