Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Excess in NADH levels induces reductive stress. Under stressed states, such as exogenous addition of Cx I substrates, hypoxia, NNT reversal, NNT inactivation, and RET, mitochondrial NADH/NAD+ increases leading to one-electron reduction of oxygen to O2•− or/and two-electron reduction of oxygen into H2O2 at respiratory Cx I. Extensive reductive ROS levels result in reductive stress, which is detrimental to cellular function. Cx I, complex I; RET, reverse electron transfer.
