Figure EV5. A global network of genetic interaction profile similarities.

1. A global genetic profile similarity network encompassing ˜3,971 non‐essential and essential genes from Costanzo et al (2016). The global similarity network was annotated using the Spatial Analysis of Functional Enrichment (SAFE) (Baryshnikova, 2016), identifying network regions enriched for similar GO biological process terms, which are color‐coded (Costanzo et al, 2016).
2. Genetic interaction enrichment landscape of TOR1, RIM15, and PHO85 in proliferating and quiescent cells under phosphorus (‐P) restriction. Each dot represents one gene. Blue dots represent genes that have negative interactions with corresponding kinase (row‐wise) in each condition (column‐wise), and yellow dots represent genes with positive interactions.