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. 2019 May 1;36(4):254–260. doi: 10.36141/svdld.v36i4.8745

Table 2.

Clinical features associated with onconeural antibody detection

Full Name Abbreviation Symptoms Associated with antibody
Acetylcholine Muscle Binding Antibody A Ch Muscl Fatigue, weakness, dysarthria, diplopia, and ptosis
Nicotinic Acetylcholine Receptor Ganglionic Neuronol Antibody A Ch Gang Bilateral numbness of the lower legs and feet, proximal lower limb muscle weakness, hypotension, ocular symptoms
Neuronol Voltage Gated Potassium Channel Antibody Neur V-G Confusion, sleep impairment, amnesia, seizure, fatigue, leg cramping, encephalitis, nausea/vomiting, ataxia, agitation
N-Type Calcium Channel Antibody N Type Ca Chan Seizures, neuralmuscular junction defect, limbic and extra-limbic autoimmune encephalopathy, neurodegenerative dementia, mild cognitive impairment, severe behavioral changes
P/Q Type Calcium Channel Antibody P/Q Type Ca Chan Limbic and extra-limbic autoimmune encephalopathy, neurodegenerative dementia, mild cognitive impairment, nonspecific cognitive disorder, severe behavioral changes, dysphagia, dysarthria, proximal muscle weakness, respiratory weakness, and seizure
Striational Antibody Striational More severe MG symptoms, high risk of arrythmias, respiratory complications, fatigue, weakness, dysarthria, diplopia, ptosis
Glutamic Acid Decarboxylase-65 antibody GAD65 Cerebellum atrophy resulting in reduced motor and cognitive function, reduced GABA levels, leg spasms, falls, lumbar pain, muscle rigidity, dizziness, vomiting, leg spasms, cerebral ataxia,
Large Granular Lymphocyte-1 immunoglobulin Antibody LGL1 Seizure, amnesia, behavioral disorders/changes, hyponatremia, FBDS, sleep disorder

MG: myasthenia gravis; GABA: gamma-aminobutyric acid; FBDS: faciobrachial dystonic seizures