Table 2.
Cox regression analysis of predictive items for death
| Group | Variable | Cox-Regression Analysis | ||
| P value | HR | 95% CI | ||
| Whole cohort | IL-6 | <0.0001 | 1.017 | 1.008 – 1.026 |
| IL-7 | 0.010 | 1.256 | 1.056 – 1.495 | |
| Pulmonary hypertension at inclusion | <0.0001 | 84.38 | 9.377 – 759.314 | |
| mRSS | 0.035 | 1.102 | 1.007 – 1.207 | |
| FVC | 0.003 | 0.959 | 0.934 – 0.986 | |
| All patients with pulmonary involvement | IL-6 | 0.012 | 1.010 | 1.002 – 1.017 |
| IL-7 | 0.001 | 1.379 | 1.139 – 1.671 | |
| Pulmonary hypertension at inclusion | <0.0001 | 48.512 | 6.039 – 389.679 | |
| FVC | 0.001 | 0.934 | 0.910 – 0.977 | |
| PAH/PH-ILD | None | |||
| ILD | IL-6 | 0.003 | 1.033 | 1.011 – 1.055 |
| FVC | 0.002 | 0.933 | 0.894 – 0.975 | |
Clinical items (gender, age, SSc form, anti-Scl-70 and anti-centromere positivity, mRSS, DLCO, FVC, lung fibrosis and/or pulmonary hypertension at inclusion) and serum cytokines were included in a Cox regression analysis in order to calculate independently predictive factors for death. Only significant items are given with the hazard ratio (HR) and the 95% confidence interval (95% CI).