Table 4.
Comparison of characteristics between the group that required dose reduction and/or discontinuation and the group that did not
| Variable | Dose reduction and/or discontinuation (n=15) | No dose reduction and/or discontinuation (n=10) | P-value |
| Male sex, n (%) | 10 (67%) | 9 (90%) | 0.390* |
| Age, years | 72 [58-79] | 67 [53-72] | 0.047† |
| Body surface area, m2 | 1.63 [1.36-1.95] | 1.78 [1.55-1.95] | 0.028† |
| %FVC, % | 65.6 [42.0-78.0] (n=13) | 69.4 [45.0-112.0] | 0.877‡ |
| %DLCO, % | 51.8 [40.0-70.0] (n=6) | 53.1 [45.0-89.0] | 0.897† |
| 6MWT, m | 339 [130-415] (n=10) | 370 [305-465] | 0.705‡ |
| %min SpO2 during 6MWT | 86.3 [80-90] (n=10) | 86.5 [75-91] | 0.760‡ |
| Krebs von den Lungen-6 | 974 [523-1520] | 1368 [656-2394] | 0.081§ |
| Albumin | 3.9 [3.1-4.4] | 4.0 [3.5-4.6] | 0.328† |
| Serum creatinine | 0.76 [0.39-1.48] | 0.76 [0.56-0.95] | 0.853§ |
| Total bilirubin | 0.81 [0.29-2.07] | 0.88 [0.38-1.62] | 1.000‡ |
| Aspartate aminotransferase | 22.5 [15.0-36.0] | 23.1 [15.0-26.0] | 0.738‡ |
| Alanine aminotransferase | 19.5 [8.0-47.0] | 22.6 [10.0-26.3] | 0.374‡ |
FVC, forced vital capacity; 6MWT, six-minute walk test; min SpO2, minimal oxygen saturation measured by pulse oximetry.
*Chi-squared test.
†Student’s t-test.
‡Mann-Whitney U test.
§Welch’s t-test.