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. 2020 Apr 28;21(9):3099. doi: 10.3390/ijms21093099

Figure 1.

Figure 1

The differences between the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro) and SARS-CoV-2 Mpro structures. (A) The overall structure of both SARS-CoV and SARS-CoV-2 Mpros with differing amino acids are marked as black (SARS-CoV Mpro) and blue (SARS-CoV-2 Mpro). (B) Close-up of the active site cavity and bound N3 inhibitor into SARS-CoV (black sticks) and SARS-CoV-2 (blue sticks) Mpros. The catalytic water molecule that resembles the position of the third member of the catalytic triad adopted from the cysteine proteases is shown for both SARS-CoV (black sphere) and SARS-CoV-2 (blue sphere) Mpros. The active site residues are shown as red sticks and the proteins’ structures are shown in surface representation. The differing residues in position 46 located near the entrance to the active site are marked with an asterisk (*) on the (A) and as blue and black lines on the (B) panel.