Mpro	Main protease
SARS	Severe acute respiratory syndrome
COVID-19	Coronavirus disease 2019
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2
CoVs	Coronaviruses
HCoV-NL63	Human coronavirus NL63
HCoV-229E	Human coronavirus 229E
HCoV-OC43	Human coronavirus OC43
HCoV-HKU1	Human coronavirus HKU1
SARS-CoV	Severe acute respiratory syndrome coronavirus
MERS-CoV	Middle East respiratory syndrome coronavirus
ORFs	Open reading frames
3CLpro	Chymotrypsin-like cysteine protease
S	Spike surface glycoprotein
E	Small envelope protein
M	Matrix protein
N	Nucleocapsid protein
N3(PRD_002214)	N-[(5 methylisoxazol-3-yl)carbonyl] alanyl-L-valyl-N~1-((1R,2Z)-4-(benzyloxy)-4-oxo-1-{[(3R)-2-oxopyrrolidin-3-yl]methyl}but-2-enyl)-L-leucinamide
cMD	Classical molecular dynamics simulations
MixMD	Mixed-solvent molecular dynamics simulations
PDB	Protein Data Bank
MAV	Maximal accessible volume
ACN	Acetonitrile
BNZ	Benzene
DMSO	Dimethylsulfoxide
MEO	Methanol
PHN	Phenol
URE	Urea
CMA	Correlated mutation analysis
FDA	Food and Drug Administration