Table 3.
Prognostic factors for progression-free survival with ovarian cancer selected by Cox’s uni- and multivariate analysis
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Hazard ratio (95%CI) | P | Hazard ratio (95%CI) | p | Hazard ratio (95%CI) | p | |
| Age (≥55) | 2.830 (1.043–7.682) | 0.041* | 1.045 (0.234–4.666) | 0.954 | 0.781 (0.163–3.731) | 0.757 |
| FIGO stage (III-IV) | 13.605 (3.157–58.631) | < 0.001* | 7.299 (1.492–35.721) | 0.014* | 9.094 (1.723–48.010) | 0.009* |
| Histopathologic type (High-grade serous carcinoma) | 3.032 (1.268–7.249) | 0.013* | 1.885 (0.505–7.031) | 0.345 | 1.937 (0.523–7.171) | 0.322 |
| Completeness of surgical reduction (Suboptimal) | 8.007 (3.239–19.795) | < 0.001* | ||||
| Treatment response (non-responders) | 16.067 (5.362–48.143) | < 0.001* | ||||
| Tumor progression (platinum-resistant) | 38.183 (10.233–142.469) | < 0.001* | ||||
| CA125 (≥399.3) | 2.730 (1.161–6.421) | 0.021* | 1.176 (0.413–3.350) | 0.762 | 0.686 (0.222–2.114) | 0.511 |
| Drp1 (≥10.5) | 11.338 (1.521–84.495) | 0.018* | 4.568 (0.551–37.879) | 0.159 | ||
| phospho-Drp1Ser637 (≥7.0) | 4.632 (1.912–11.220) | 0.001* | 3.151 (1.039–9.561) | 0.043* | ||
| CaMKI (≥10.5) | 2.864 (1.161–7.065) | 0.022* | 1.809 (0.690–4.744) | 0.228 | 2.740 (0.997–7.532) | 0.051 |
* p < 0.05