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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Int J Hematol. 2019 Dec 4;111(5):622–627. doi: 10.1007/s12185-019-02787-8

Fig. 1. Updated layered immune model.

Fig. 1.

This schema updated and modified the figure proposed by Montecino-Rodriguez and Dorshkind[18]. The first B cell-wave is derived from the hemogenic endothelial cells in the YS/P-Sp at around E8.5-9.5. B cells from this wave are B-1 lymphocyte biased[20]. The second wave is derived from presumably pre-HSCs or HSCs at an early stage of fetal liver. This second wave seems to be the main source of B-1a cells, and also starts to produce B-2 cells. The third wave is derived from HSCs in the post-natal BM, generating mainly B-2 cells with minimum numbers of B-1 cells.