Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 4;21(9):3244. doi: 10.3390/ijms21093244

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic representation of human estrogen receptors (ERα) protein. ERα protein exhibits six domains, A to F, oriented from the amino (N) to carboxyl (C) terminus. The domains which locate key functions are indicated: activation function (AF)-1 and AF-2 mediate transcriptional activity. The DNA binding domain (DBD) interacts with estrogen responsive element (ERE) DNA motifs, and the ligand binding domain (LBD) binds E2. H is the hinge domain. Helix 12 (H12) interacts with transcriptional activators and repressors following ligand binding.