Table 3.

Summary of studies focusing on miRNA profiles in colorectal cancer (CRC) adenomas (in chronological order).

Reference	Origin of Study	Source	Number of Patients	miRNAs	Significant Relevant
[89]	USA	tissue	84 adenomas	miR-21	↑ expression associated with poor survival
[90]	Netherlands	tissue	25 CRC 30 adenomas	miR-17-92 cluster	↑ expression across adenoma carcinoma sequence
[81]	USA	tissue	222 CRC 41 adenomas 52 controls	miR-135b miR-31 miR-1 miR-137 miR-9 miR-99a	ability to distinguish adenomas vs. controls
[91]	USA	plasma	20 CRC 9 adenomas 12 controls	miR-532 miR-331 miR-195 miR-17 miR-142 miR-15b miR-532 miR-652 miR-15b miR-21 miR-339	ability to distinguish adenomas vs. controls and CRC
[83]	China	tissue	227 adenomas 37 controls	miR-194a	predictor for adenoma recurrence
[88]	China	tissue	40 CRC 16 adenomas	miR-31 miR-135b	↑ expression in adenoma carcinoma sequence
		stool	104 CRC 169 adenomas 109 controls		↑ expression in stool miR-135 level across the adenoma carcinoma sequence
[82]	Japan	tissue	870 CRC 637 adenomas	miR-31	↑ miR-31 expression was associated with CIMP status
[92]	USA	tissue	113 adenomas	miR-320a	↑ expression in adenoma carcinoma sequence
				miR-145 miR-192	↓ expression across adenoma carcinoma sequence
[93]	China	serum	307 CRC 164 adenomas 266 controls	miR19a miR-92a miR-223a	↑ expression in adenoma carcinoma sequence
				miR-422	↓ expression across adenoma carcinoma sequence
[80]	UK	tissue	13 CRC 55 adenomas 10 controls	miR-135b	↑ expression across adenoma carcinoma sequence
[94]	Netherlands	tissue	52 CRC 48 adenomas	miR-15a	↑ expression in adenoma carcinoma sequence
[95]	France	tissue	41 CRC 51 adenomas 34 controls	miR-15b miR-16b miR-21 miR-24 miR-145 miR-150 miR-378	↓ expression in adenomas compared to controls
[96]	Japan	tissue	151 CRC 21 adenomas	miR-148a	↓ expression across adenoma carcinoma sequence
[97]	USA	serum	11 CRC 20 adenomas 10 controls	miR-30b miR-30c miR-146a miR-30d	↑ expression in adenoma carcinoma sequence
[98]	Japan	tissue	18 CRC with adenomas 3 CRC without adenomas 21 normal mucosa	miR-320 family	↓ expression in adenomas and early CRC tissue vs. controls
[78]	USA	tissue	109 adenomas	miR-145 miR-143 miR-107a miR-194 miR-26a miR-663b miR-1268 miR-320a miR-1275	ability to distinguish high risk adenomas from low risk adenomas
[86]	Japan	serum (+exosomes)	26 adenomas 47 controls	miR-21 miR-29a miR-92a miR-135b	ability to distinguish adenomas vs. controls discriminate patients with ↑ risk adenoma
[85]	Hungary	tissueplasma	20 CRC 20 adenomas 20 controls	miR-31 miR-10b miR-183 miR-196a	expression of miRNAs in plasma correlated with matched tissue expression level ability to distinguish adenomas vs. controls and CRC
[99]	China	serum	20 CRC 20 adenomas 20 controls	miR-4463 miR-5704 miR-371b miR-1247 miR-1293 miR-548a miR-107 miR-139	ability to distinguish CRC vs. adenomas vs. controls
[100]	USA	serum	34 CRC 33 adenomas 35 controls	Ratios of: let-7b/miR-367 miR-130a/miR-409 miR-148/miR-27 miR-148/miR-409 miR-21-miR367	ability to distinguish adenoma vs. controls
				miR-17/miR-135b miR-92a/miR-135b miR-451a/miR-491	ability to distinguish CRC vs. adenomas
[84]	Colombia	tissue serum	45 CRC 25 adenomas 45 controls	miR-141 miR-200c	↑ expression in adenomas compared to CRC and controls
[79]	USA	tissue	26 adenomas 30 controls	miR-31 miR-135b miR-378a	predictors of serrated neoplasia
[101]	Ireland	plasma	16 CRC 24 adenomas 8 controls	miR-34 miR-150	ability to distinguish CRC vs. adenomas
[76]	China	tissue	6 CRC 6 adenomas 6 controls	miR-135b miR-18a miR-29b	↑ expression in adenoma carcinoma sequence
				miR-1 miR-338 miR-218	↓ expression level across adenoma carcinoma sequence

↑ high/higher, ↓ low/lower.